Firstly, What Is NMN?
NMN (also known as ‘nicotinamide mononucleotide’, if you want to get scientific) is a building block of an essential molecule called NAD+. NAD+ is an essential molecule that plays an important role in energy metabolism and healthy cell function. The older we get, the more the NAD+ levels in our cells decline - and this is a major contributor to the symptoms of ageing.
Low levels of NAD+ are associated with:
Declined metabolism, which leads to weight gain and an increased risk of metabolic syndrome and other disorders
- Age-related muscle loss
- Ageing-related cognitive decline
- Ageing-related eyesight and hearing loss
- Reduced blood vessel health
- Shorter lifespan
One of the fastest ways to stimulate your body’s NAD+ production is to supplement with NMN. Taking an NMN supplement has been researched to reduce age-related weight gain, prevent age-linked changes in gene expression, and enhance energy metabolism, physical activity, insulin sensitivity, eye function and mitochondrial metabolism. NMN supplements can also help to alleviate metabolic conditions like obesity.
Other NAD+ Supplements & Precursors
There are many NAD+ precursors available on the market - as well as NAD+ supplements themselves - but research shows that NMN is the best supplement to take if you are wanting to combat the ageing process.
NR(Nicotinamide Riboside) Supplements
Research indicates that NR consumption can increase NAD+ levels safely and effectively and combat the effects of ageing. However, NMN is believed to be a superior supplement, because once it is inside the cell, it is one step closer than NR to becoming NAD+. The pathway that leads to NAD+ is as follows: NR => NMN => NAD+ => DNA repair and epigenetic maintenance. This means that NR is converted into NMN, and then NMN is used to build NAD+. So, when compared to NR, NMN is one step further down the pathway to producing NAD+. If you want to hear more about the benefits of NMN over NR, Dr Rhonda Patrick and David Sinclair discuss the differences in this interview.
Research shows that taking a precursor to NAD+ is better than taking direct NAD+ because NAD+ molecules are too large and not easily absorbed by the body. When you take a precursor, the body converts it into NAD+ to provide a slow and steady supply of cellular energy. NAD+ has to be broken down into smaller building blocks before being passed into the cell - but you can bypass this process by simply taking the building block NMN, which is more easily absorbed into the bloodstream, and also shows additional benefits like a stronger effect on physical health and endurance.
Nicotinic Acid or Niacin Supplements
Niacin is a form of vitamin B3 and another building block for NAD+. Niacin is an important nutrient - pretty much every part of your body needs it to function properly. Niacin supplements can lower cholesterol, improve arthritis and boost brain function. However, they have also been shown to have a range of negative side effects, like skin flushing, increasing allergies and reduced insulin sensitivity. Niacin also doesn’t appear to be an NAD+ precursor in the most important cells (like neurons, brain cells and skeletal muscle cells, which are the ones that are most affected by ageing). Overall, niacin doesn’t seem to provide the full range of anti-ageing benefits that NMN does.
NAM (Nicotinamide) Supplements
NAM is another form of B3 that plays an important role in energy metabolism and cell health, and taking NAM supplements can be used to increase energy, improve memory, lower blood pressure, and lower cholesterol. However, NAM comes with its disadvantages - it has been shown to inhibit sirtuin activity (sirtuins are a vital protein for various cellular processes like cell maintenance and DNA repair) and harm insulin sensitivity. Its anti-aging benefits also appear to decline with age (because the older we get, the less NAD gets generated from nicotinamide). The benefits also become less available in cases of inflammation or obesity, and overall don’t appear to replenish NAD+ efficiently when people need it most.
What We Want Is the Best Precursor for NAD+
All these NAD+ precursors have their benefits - but what you really want is NAD+ in the fastest, most efficient way possible. Oral NMN supplements are rapidly absorbed and converted to NAD+. According to various studies, including the ‘The Science Behind NMN-A Stable, Reliable NAD+ Activator and Anti-Ageing Molecule’ study by Christopher Shade, NMN has been able to suppress age-associated weight gain, enhance energy metabolism and physical activity, improve insulin sensitivity, improve eye function, improve mitochondrial metabolism and prevent age-linked changes in gene expression.
NMN supplements can also help to relieve metabolic conditions like fatty liver and obesity. Supplementing with NMN can be an effective anti-ageing intervention and have all sorts of beneficial effects on a wide range of physiological functions. By supplementing wisely with NMN capsules, you can restore the levels of NAD+ in your body and combat the signs and symptoms of ageing.
If you have any questions about NAD+ supplements or the benefits of NMN, don’t hesitate to contact us.
*Please note, the content of this article is for informational purposes only. It is not a substitute for professional medical advice, diagnosis or treatment.