Disclaimer: Dr David Sinclair does not endorse any NMN brand or product and the information provided in this article is purely informational.
Dr David Sinclair is a NMN advocate, researcher, consumer and well-known authority on NMN (nicotinamide mononucleotide).
If you’re considering taking NMN and would like to know Dr Sinclair’s NMN intake and daily dosage, it’s all here.
In addition to supplementation, Dr Sinclair maintains a healthy, balanced lifestyle with an emphasis on intermittent fasting, exercise and a diet rich in plant-based foods.
Through this combination of supplementation and healthy habits, Dr. Sinclair aims to slow down the aging process and promote longevity.
Following his own research findings, Dr. Sinclair incorporates a daily dose of NMN supplementation into his daily routine, along with other anti-aging supplements like resveratrol.
Who Is Dr. David Sinclair And What Does He Do Exactly?
Dr. Sinclair is a Professor of Genetics at Harvard University, and a leading expert and pioneer in the field of aging and longevity.
In his best-selling book, Lifespan: Why We Age & Why We Don't Have To, Dr. Sinclair explores the possibility of delaying and even reversing the aging process.
He strongly believes that living up to 150 years or longer is achievable, and his own biological or epigenetic age is much younger than his chronological age.
Sinclair's research primarily focuses on potential compounds that may slow down aging, such as NMN.
NMN is an NAD+ precursor that has shown promise in the longevity arena.
Dr. Sinclair has identified several other supplements and medications that he believes may contribute to increased longevity and healthspan.
Aside from his academic work, Sinclair is also the co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School.
His dedication to understanding and promoting healthy aging has earned him international recognition and widespread respect within the scientific community.
How David Sinclair Became Known As An Anti-Aging Expert
Dr Sinclair is an Australian-American biologist and academic who has built a reputation as a leading expert in the field of anti-aging research.
His scientific journey began at a young age when he became fascinated by the mysteries of life and aging.
Dr Sinclair's research has largely focused on understanding the role of sirtuins, a family of proteins found in almost all organisms.
These enzymes play a crucial role in regulating metabolism and aging.
He first gained international recognition for his work on yeast sirtuin Sir2 during his postdoctoral fellowship at MIT.
As he continued to study sirtuins, Dr Sinclair discovered their potential in combating age-related diseases and extending lifespan.
One of the significant breakthroughs in Dr Sinclair's research was the identification of NMN as a potent NAD+ precursor.
NAD+ is a critical coenzyme required for cellular metabolism and energy production.
As organisms age, NAD+ levels decline, leading to a slowing down of metabolic processes and cellular damage.
NMN has been shown to effectively restore NAD+ levels, potentially slowing down the aging process and improving overall health.
Dr Sinclair's work extends beyond the laboratory, as he is a well-known author and advocate for healthy aging.
His book, "Lifespan", has garnered much attention and praise for its detailed explanations and aspirational vision of a future where humans can live longer, healthier lives.
Throughout his career, David Sinclair has been recognized for his innovative research, dedication to understanding the aging process and commitment to sharing his knowledge with the broader public.
As a result, he has become a respected and influential figure in the field of anti-aging, with many anticipating the continued advancements and discoveries to come from his work.
David Sinclair NMN Dosage
Dr. Sinclair has reported that he personally takes a daily NMN dosage of 1 gram with his morning beverage.
This dose is considered to be on the higher end of the spectrum, as many recommendations for NMN intake suggest starting with lower doses.
For most individuals, the minimum recommended dose is 250 mg of NMN per day, which can be taken in the form of 2 capsules at 125 mg each or one 500mg NMN capsule with 99% purity.
It is essential to strike a balance between obtaining the benefits of NMN and not causing any potential adverse side effects.
The suggested NMN dosages are based on individual needs and preferences.
Some may want to experiment with higher doses similar to Dr Sinclair's intake, but it is crucial to be aware of the potential risks and consult with a healthcare professional before making any changes in supplement dosages.
Choose a NMN product with Good Manufacturing Practices (GMP) certification to ensure that it is of high quality.
It is advised to avoid purchasing NMN from unreliable sources, such as unknown online retailers or platforms like Amazon, as the quality of the product may be compromised.
David Sinclair Supplements Stack
Dr. Sinclair follows a meticulously designed supplement stack to support his health and longevity.
On the top of Dr Sinclair’s supplement list is NMN, which as mentioned above is a daily dosage of 1 gram (1000mg).
This high dose of NMN aims to boost his NAD+ levels, an essential molecule for numerous cellular processes.
In addition to NMN, Dr. Sinclair also incorporates resveratrol in his daily routine.
He consumes 1 gram of resveratrol each morning as it is known for its antioxidant and anti-inflammatory properties, thus supporting overall health and wellbeing.
Dr. Sinclair's supplement stack goes beyond NMN and resveratrol.
This is exact stack of supplements he takes according to this book Lifespan:
- Nicotinamide mononucleotide (NMN): 1 g
- Resveratrol: 1 g
- Metformin: 800 mg
- Spermidine: 1 mg
- Quercetin: 500 mg
- Fisetin: 500 mg
- Vitamin D3: 4,000 to 5,000 IU
- Vitamin K2: 180 to 360 mcg
- Low-dose aspirin: 81 mg
- Trimethylglycine (TMG): 500 to 1,000 mg
- Rapamycin: N/A
Each compound plays a specific role in supporting various aspects of health, from insulin sensitivity to cellular repair and overall longevity.
It is important to note that this supplement routine is not his recommendation. It is him disclosing his personal routine.
Some other notable supplements in Dr. Sinclair's stack are:
- Alpha Lipoic Acid (ALA)
- Coenzyme Q10
Pterostilbene, a molecule similar to resveratrol, showcases its potential in fighting oxidative stress and inflammation.
Alpha lipoic acid is a powerful antioxidant that also plays a crucial role in energy metabolism.
And Coenzyme Q10 is a vital component for cellular energy production and overall heart health.
In summary, Dr. Sinclair's supplement stack reflects his extensive knowledge and research in the field of aging science.
By combining the power of multiple supplements including NMN, resveratrol and others, he aims to optimize his health and pave the way for a longer, healthier life.
Diets And Habits: A Look Into David Sinclair's Longevity Lifestyle
As Dr. Sinclair is known for his work in the field of longevity, many people are curious about his personal longevity diet and habits.
His diet primarily consists of plant-based foods with a very low intake of sugar and starchy foods such as pasta, potatoes and processed foods.
He often consumes probiotic-rich yogurt throughout the day and opts for green matcha tea over coffee, complemented with polyphenols in a couple of spoonfuls of yogurt in the mornings.
In addition to his diet, Dr Sinclair incorporates certain fasting practices for optimal health, including popular time-restricted feeding protocols like 18:6 intermittent fasting, where one fasts for 18 hours and eats for 6, or 20:4 fasting, where one fasts for 20 hours and eats for 4.
His fasting routine includes at least 16 hours of not eating or minimal eating to reap the benefits of fasting.
Exercise is also a vital part of Sinclair's lifestyle.
While specific details about his exercise routine are not known specifically, maintaining an active lifestyle is generally recommended to work in tandem with diet and fasting practices for promoting overall health and longevity.
Furthermore, Dr Sinclair suggests that even moderate consumption of red wine might not be beneficial for one's health in the long run, and he therefore refrains from all forms of alcohol.
This contradicts the common belief that a moderate intake of red wine is good due to its resveratrol content.
His approach to alcohol challenges popular beliefs and highlights the importance of tailoring one's lifestyle to their body and specific needs.
Research Findings: Influence Of NMN On Lifespan
NMN has garnered significant attention in the scientific community as a potential anti-aging compound.
As a precursor to NAD+, NMN plays a vital role in several cellular processes and energy metabolism.
In one of Dr Sinclair’s research studies, he and his team observed male mice to investigate the effects of NMN on aging.
They found that NMN supplementation led to improvements in age-associated weight gain, enhanced energy metabolism, and increased physical activity.
NMN also displayed positive effects on insulin sensitivity and eye function.
Other studies have suggested that NMN can alleviate or even reverse age-related conditions by stimulating NAD+ metabolism.
Apart from NMN, resveratrol is another well-known compound with potential anti-aging properties.
Resveratrol is believed to activate the same pathways as NMN, promoting longevity and healthy aging.
Another aspect of anti-aging research is focused on the clearing of senescent cells.
These are cells that cease to divide and can contribute to age-related diseases.
Dr Sinclair's research has indicated that increasing NAD+ levels through NMN supplements could potentially reduce the number of these senescent cells, resulting in a healthier and more youthful cellular environment.
In recent human trials, Dr Sinclair and his colleagues have explored the use of small molecule cocktails to reverse cellular aging.
Their findings, published in the journal Aging, showed that these cocktails can effectively transform cells back to their stem cell state, leading to a reversal of the aging process.
While the research conducted thus far is promising, it's important to note that clinical trials are still ongoing to determine the exact impact of NMN and related compounds on human aging and lifespan.
Further research is required to ascertain the overall effectiveness and long-term safety of these compounds before making any conclusive claims about their potential benefits in combating aging and age-related diseases.
David Sinclair’s Labs (Blood Test Results)
One of the key markers that Dr Sinclair regularly tracks is the NAD+ level in his blood.
Supplementing with NMN, a precursor to NAD+, may help to elevate and maintain NAD+ levels, which could ultimately mitigate the aging process and improve several aspects of health.
According to reports, Sinclair has observed a significant increase in his own NAD+ levels after taking NMN.
In addition to NAD+ levels, Sinclair also monitors a range of other blood markers that are commonly associated with aging and age-related diseases.
These markers include:
- Lipid profiles
- Mitochondrial function
By keeping an eye on these markers, Dr Sinclair can fine-tune his personal supplementation protocol to ensure optimal health and longevity benefits are achieved.
While Dr Sinclair’s blood test results aren’t public knowledge, he does make public his personal blood markers that he tracks along with general recommendations to longevity-focused consumers.
By carefully monitoring his own health markers, Dr Sinclair is dedicated to not only furthering his research in the field of aging science but also paving the way to a healthier future for all.
Sinclair’s Test: The David Sinclair Biological Age Test
Dr Sinclair is known for the Information Theory of Aging (ITA) and has consequently developed an aging test.
‘Sinclair’s Test’ is a biological age assessment test based on years of research by Dr Sinclair on how the body ages.
While many still believe that our genetics determine our health outcomes, Dr Sinclair places more emphasis on the impact of epigenetics, which is how our environment and lifestyle choices positively or negatively impact our health.
What Is David Sinclair’s Research Lab Working On?
David Sinclair and his colleagues conduct extensive research on the cellular and molecular mechanisms of aging, employing cutting-edge techniques and knowledge derived from numerous studies.
Their work covers a broad spectrum of topics, from epigenetics to age-related diseases, in an effort to improve the understanding of the aging process and develop novel strategies to slow it down or even reverse it.
David Sinclair’s Diet: What He Eats (Including NMN Foods)
Dr. Sinclair has gained attention for his personal dietary habits that could potentially promote longevity through nutrition.
His diet primarily focuses on plant-based foods, minimal sugar and low intake of starchy items such as pasta and bread.
He also focuses on incorporating NMN foods in his diet, which are known to boost the production of NAD+, a critical molecule for cellular energy and repair.
During the day, Dr Sinclair consumes probiotic-rich yogurt mixed with polyphenols, which are plant-derived molecules with anti-inflammatory effects.
One of the key polyphenols he adds to the yogurt is resveratrol, a compound found in red grapes that has exhibited anti-aging benefits in rodent studies.
Aside from yogurt, Dr Sinclair's diet comprises plenty of nutrient-rich fruits, vegetables, legumes, seeds, and nuts which are all packed with essential vitamins, minerals and antioxidants.
These also include NMN food sources that are rich in vitamin B3 such as mushrooms, tomatoes, cucumbers, broccoli, avocados, and almonds.
In addition to a well-balanced plant-based diet, Dr Sinclair also takes specific supplements, such as quercetin and fisetin, both of which he typically consumes with yogurt.
These supplements can potentially further boost the effects of a health-promoting diet and support overall longevity.
Which NMN brand does David Sinclair use?
The Dr David Sinclair NMN brand of choice has not been stated by him publicly and he doesn’t endorse any specific brand either.
However, he has mentioned in interviews that he takes a daily dose of 1,000 mg of NMN.
The best NMN supplement David Sinclair would be taking would likely be high-purity, non-GMO, contain no fillers, made in a GMP facility, third-party certified for purity and toxic-free.
It is important to note that the effects and safety of long-term use of NMN in humans are yet to be scientifically established, and it is always recommended to consult a healthcare professional before starting any supplementation regimen.
Where can natural sources of NMN be found?
High NMN containing sources are limited as it is a compound that is primarily synthesized within the body.
However, certain foods contain precursors or other compounds that can aid in the production of NMN.
These foods include:
While consuming these foods may help support the biosynthesis of NMN, the most effective way to supplement NMN is through oral supplementation, as the levels found in foods are generally lower than what can be achieved through supplementation.
How old is Dr. David Sinclair?
Dr. David Sinclair was born on June 26, 1969. He’s 54 years old.
Dr. Sinclair is highly respected for his research in the field of aging and has made significant contributions to our understanding of the molecular processes that underlie cellular aging.
He has authored numerous scientific publications and is considered a leading authority in the field of aging research.
Dr Sinclair is globally-recognized NMN expert who has conducted in-depth research into the benefits of NMN to slow aging.
Dr Sinclair takes NMN daily as part of his longevity protocol and believes it contributes positively to the fact his biological age is younger than his chronological age.
Dr Sinclair believes that looking and feeling younger begins with making changes today, from diet to supplements to activity levels.
Find out more about AlphaCell’s 99.5% pure NMN as a potential addition to your longevity protocol.
Disclaimer: Dr David Sinclair does not endorse any NMN brand or product and the information provided in this article is purely informational.